Chikungunya Vaccine Candidate Is Highly Attenuated and Protects Nonhuman Primates Against Telemetrically Monitored Disease Following a Single Dose

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes major epidemics of rash, fever, and debilitating arthritis. Currently, there are no vaccines or antivirals available for prevention or treatment. We therefore generated 2 live-attenuated vaccine candidates based on the insertion of...

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Bibliographische Detailangaben
Hauptverfasser: Roy, Chad J., Adams, A. Paige, Wang, Eryu, Plante, Kenneth, Gorchakov, Rodion, Seymour, Robert L., Vinet-Oliphant, Heather, Weaver, Scott C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
Major Articles and Brief Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038141/
https://ncbi.nlm.nih.gov/pubmed/24403555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiu014
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