Chikungunya Vaccine Candidate Is Highly Attenuated and Protects Nonhuman Primates Against Telemetrically Monitored Disease Following a Single Dose

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes major epidemics of rash, fever, and debilitating arthritis. Currently, there are no vaccines or antivirals available for prevention or treatment. We therefore generated 2 live-attenuated vaccine candidates based on the insertion of...

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Hlavní autoři: Roy, Chad J., Adams, A. Paige, Wang, Eryu, Plante, Kenneth, Gorchakov, Rodion, Seymour, Robert L., Vinet-Oliphant, Heather, Weaver, Scott C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
Major Articles and Brief Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038141/
https://ncbi.nlm.nih.gov/pubmed/24403555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiu014
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