Ribosomal Biogenesis and Translational Flux Inhibition by the Selective Inhibitor of Nuclear Export (SINE) XPO1 Antagonist KPT-185

Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma characterized by the aberrant expression of several growth-regulating, oncogenic effectors. Exportin 1 (XPO1) mediates the nucleocytoplasmic transport of numerous molecules including oncogenic growth-regulating factors, RNAs, and ribosomal...

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Publicado en:PLoS One
Autores principales: Tabe, Yoko, Kojima, Kensuke, Yamamoto, Shinichi, Sekihara, Kazumasa, Matsushita, Hiromichi, Davis, Richard Eric, Wang, Zhiqiang, Ma, Wencai, Ishizawa, Jo, Kazuno, Saiko, Kauffman, Michael, Shacham, Sharon, Fujimura, Tsutomu, Ueno, Takashi, Miida, Takashi, Andreeff, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560410/
https://ncbi.nlm.nih.gov/pubmed/26340096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137210
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