Bone marrow adipocytes facilitate fatty acid oxidation activating AMPK and a transcriptional network supporting survival of acute monocytic leukemia cells

Leukemia cells in the bone marrow (BM) must meet the biochemical demands of increased cell proliferation and also survive by continually adapting to fluctuations in nutrient and oxygen availability. Thus, targeting metabolic abnormalities in leukemia cells located in the BM is a novel therapeutic ap...

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Publicado no:Cancer Res
Main Authors: Tabe, Yoko, Yamamoto, Shinichi, Saitoh, Kaori, Sekihara, Kazumasa, Monma, Norikazu, Ikeo, Kazuho, Mogushi, Kaoru, Shikami, Masato, Ruvolo, Vivian, Ishizawa, Jo, Hail, Numsen, Kazuno, Saiko, Igarashi, Mamoru, Matsushita, Hiromichi, Yamanaka, Yasunari, Arai, Hajime, Nagaoka, Isao, Miida, Takashi, Hayashizaki, Yoshihide, Konopleva, Marina, Andreeff, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354955/
https://ncbi.nlm.nih.gov/pubmed/28108519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1645
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