Bone marrow adipocytes facilitate fatty acid oxidation activating AMPK and a transcriptional network supporting survival of acute monocytic leukemia cells

Leukemia cells in the bone marrow (BM) must meet the biochemical demands of increased cell proliferation and also survive by continually adapting to fluctuations in nutrient and oxygen availability. Thus, targeting metabolic abnormalities in leukemia cells located in the BM is a novel therapeutic ap...

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Bibliografski detalji
Izdano u:Cancer Res
Glavni autori: Tabe, Yoko, Yamamoto, Shinichi, Saitoh, Kaori, Sekihara, Kazumasa, Monma, Norikazu, Ikeo, Kazuho, Mogushi, Kaoru, Shikami, Masato, Ruvolo, Vivian, Ishizawa, Jo, Hail, Numsen, Kazuno, Saiko, Igarashi, Mamoru, Matsushita, Hiromichi, Yamanaka, Yasunari, Arai, Hajime, Nagaoka, Isao, Miida, Takashi, Hayashizaki, Yoshihide, Konopleva, Marina, Andreeff, Michael
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354955/
https://ncbi.nlm.nih.gov/pubmed/28108519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1645
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