Bone marrow adipocytes facilitate fatty acid oxidation activating AMPK and a transcriptional network supporting survival of acute monocytic leukemia cells

Leukemia cells in the bone marrow (BM) must meet the biochemical demands of increased cell proliferation and also survive by continually adapting to fluctuations in nutrient and oxygen availability. Thus, targeting metabolic abnormalities in leukemia cells located in the BM is a novel therapeutic ap...

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Detaylı Bibliyografya
Yayımlandı:Cancer Res
Asıl Yazarlar: Tabe, Yoko, Yamamoto, Shinichi, Saitoh, Kaori, Sekihara, Kazumasa, Monma, Norikazu, Ikeo, Kazuho, Mogushi, Kaoru, Shikami, Masato, Ruvolo, Vivian, Ishizawa, Jo, Hail, Numsen, Kazuno, Saiko, Igarashi, Mamoru, Matsushita, Hiromichi, Yamanaka, Yasunari, Arai, Hajime, Nagaoka, Isao, Miida, Takashi, Hayashizaki, Yoshihide, Konopleva, Marina, Andreeff, Michael
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354955/
https://ncbi.nlm.nih.gov/pubmed/28108519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1645
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