Hypoxia inducible factor-1-dependent up-regulation of BMP4 mediates hypoxia-induced increase of TRPC expression in PASMCs

AIMS: Previously we demonstrated that both hypoxia inducible factor-1 (HIF-1) and bone morphogenetic protein-4 (BMP4) up-regulate transient receptor potential canonical (TRPC) 1 and TRPC6, resulting in increased basal intracellular Ca(2+) concentration ([Ca(2+)](i)) in pulmonary arterial smooth musc...

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Detalhes bibliográficos
Publicado no:Cardiovasc Res
Main Authors: Wang, Jian, Fu, Xin, Yang, Kai, Jiang, Qian, Chen, Yuqin, Jia, Jing, Duan, Xin, Wang, Elizabeth W., He, Jianxing, Ran, Pixin, Zhong, Nanshan, Semenza, Gregg L., Lu, Wenju
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560045/
https://ncbi.nlm.nih.gov/pubmed/25824146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvv122
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