Serum RANKL levels associate with anti- citrullinated protein antibodies in early untreated rheumatoid arthritis and are modulated following methotrexate

INTRODUCTION: Receptor activator of nuclear factor kappa B ligand (RANKL) is a key regulator of bone metabolism. Anti-citrullinated protein antibodies (ACPA) have been suggested to cause bone destruction by osteoclast activation. We investigated the relationship between RANKL and ACPA in patients wi...

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Pubblicato in:Arthritis Res Ther
Autori principali: Hensvold, Aase Haj, Joshua, Vijay, Li, Wanying, Larkin, Michaela, Qureshi, Ferhan, Israelsson, Lena, Padyukov, Leonid, Lundberg, Karin, Defranoux, Nadine, Saevarsdottir, Saedis, Catrina, Anca Irinel
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4559929/
https://ncbi.nlm.nih.gov/pubmed/26337028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0760-9
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