Tocilizumab decreases T cells but not macrophages in the synovium of patients with rheumatoid arthritis while it increases the levels of serum interleukin-6 and RANKL

OBJECTIVES: Our knowledge about the effect of tocilizumab (TCZ) on the synovium in rheumatoid arthritis (RA) is limited. The aim of this study was to investigate the effect of TCZ on citrullination and on inflammation in the synovial tissue and in the peripheral blood. METHODS: 15 patients with RA u...

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Publicado en:RMD Open
Main Authors: Chatzidionysiou, Katerina, Circiumaru, Alexandra, Rethi, Bence, Joshua, Vijay, Engstrom, Marianne, Hensvold, Aase, af Klint, Erik, Catrina, Anca
Formato: Artigo
Idioma:Inglês
Publicado: BMJ Publishing Group 2021
Assuntos:
Rheumatoid Arthritis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8194335/
https://ncbi.nlm.nih.gov/pubmed/34112702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/rmdopen-2021-001662
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