Examination of the Effects of Heterogeneous Organization of RyR Clusters, Myofibrils and Mitochondria on Ca(2+) Release Patterns in Cardiomyocytes

Spatio-temporal dynamics of intracellular calcium, [Ca(2+)](i), regulate the contractile function of cardiac muscle cells. Measuring [Ca(2+)](i) flux is central to the study of mechanisms that underlie both normal cardiac function and calcium-dependent etiologies in heart disease. However, current i...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Rajagopal, Vijay, Bass, Gregory, Walker, Cameron G., Crossman, David J., Petzer, Amorita, Hickey, Anthony, Siekmann, Ivo, Hoshijima, Masahiko, Ellisman, Mark H., Crampin, Edmund J., Soeller, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4559435/
https://ncbi.nlm.nih.gov/pubmed/26335304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004417
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