Comprehensive metabolome analyses reveal N-acetylcysteine-responsive accumulation of kynurenine in systemic lupus erythematosus: implications for activation of the mechanistic target of rapamycin

Systemic lupus erythematosus (SLE) patients exhibit depletion of the intracellular antioxidant glutathione and downstream activation of the metabolic sensor, mechanistic target of rapamycin (mTOR). Since reversal of glutathione depletion by the amino acid precursor, N-acetylcysteine (NAC), is therap...

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Detalhes bibliográficos
Publicado no:Metabolomics
Main Authors: Perl, Andras, Hanczko, Robert, Lai, Zhi-Wei, Oaks, Zachary, Kelly, Ryan, Borsuk, Rebecca, Asara, John M., Phillips, Paul E.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4559110/
https://ncbi.nlm.nih.gov/pubmed/26366134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11306-015-0772-0
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