The viral context instructs the redundancy of costimulatory pathways in driving CD8(+) T cell expansion

Signals delivered by costimulatory molecules are implicated in driving T cell expansion. The requirements for these signals, however, vary from dispensable to essential in different infections. We examined the underlying mechanisms of this differential T cell costimulation dependence and found that...

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Veröffentlicht in:eLife
Hauptverfasser: Welten, Suzanne PM, Redeker, Anke, Franken, Kees LMC, Oduro, Jennifer D, Ossendorp, Ferry, Čičin-Šain, Luka, Melief, Cornelis JM, Aichele, Peter, Arens, Ramon
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2015
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558566/
https://ncbi.nlm.nih.gov/pubmed/26263500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07486
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