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DRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma

Glaucoma is the leading cause of irreversible blindness and is characterized by slow and progressive degeneration of the optic nerve head axons and retinal ganglion cell (RGC), leading to loss of visual function. Although oxidative stress and/or alteration of mitochondrial (mt) dynamics induced by e...

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Détails bibliographiques
Publié dans:Cell Death Dis
Auteurs principaux: Kim, K-Y, Perkins, G A, Shim, M S, Bushong, E, Alcasid, N, Ju, S, Ellisman, M H, Weinreb, R N, Ju, W-K
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558491/
https://ncbi.nlm.nih.gov/pubmed/26247724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.180
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