Inhibition of cyclophilin D by cyclosporin A promotes retinal ganglion cell survival by preventing mitochondrial alteration in ischemic injury

Cyclosporin A (CsA) inhibits the opening of the mitochondrial permeability transition pore (MPTP) by interacting with cyclophilin D (CypD) and ameliorates neuronal cell death in the central nervous system against ischemic injury. However, the molecular mechanisms underlying CypD/MPTP opening-mediate...

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Detalhes bibliográficos
Main Authors: Kim, S Y, Shim, M S, Kim, K-Y, Weinreb, R N, Wheeler, L A, Ju, W-K
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973219/
https://ncbi.nlm.nih.gov/pubmed/24603333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.80
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