Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells

Impairment of mitochondrial structure and function is strongly linked to glaucoma pathogenesis. Despite the widely appreciated disease relevance of mitochondrial dysfunction and loss, the molecular mechanisms underlying mitochondrial fragmentation and metabolic stress in glaucoma are poorly understo...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Edwards, Genea, Perkins, Guy A., Kim, Keun-Young, Kong, YeEun, Lee, Yonghoon, Choi, Soo-Ho, Liu, Yujia, Skowronska-Krawczyk, Dorota, Weinreb, Robert N., Zangwill, Linda, Strack, Stefan, Ju, Won-Kyu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7170863/
https://ncbi.nlm.nih.gov/pubmed/32312949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2456-6
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