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The structural role of antibody N-glycosylation in receptor interactions
Asparagine(N)297-linked glycosylation of IgG Fc is required for binding to FcγRIIa, IIb and IIIa though it is unclear how it contributes. We found the quaternary structure of glycosylated Fc was indistinguishable from aglycosylated Fc indicating N-glycosylation does not maintain relative Fc Cγ2/Cγ3...
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| Опубликовано в: : | Structure |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4558368/ https://ncbi.nlm.nih.gov/pubmed/26211613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.06.015 |
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