Restricted processing of CD16a/Fc γ receptor IIIa N-glycans from primary human NK cells impacts structure and function

CD16a/Fc γ receptor IIIa is the most abundant antibody Fc receptor expressed on human natural killer (NK) cells and activates a protective cytotoxic response following engagement with antibody clustered on the surface of a pathogen or diseased tissue. Therapeutic monoclonal antibodies (mAbs) with gr...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Patel, Kashyap R., Roberts, Jacob T., Subedi, Ganesh P., Barb, Adam W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846152/
https://ncbi.nlm.nih.gov/pubmed/29330305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001207
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