MEK inhibitor PD-0325901 overcomes resistance to PI3K/mTOR inhibitor PF-5212384 and potentiates anti-tumor effects in human head and neck squamous cell carcinoma

PURPOSE: Head and neck squamous cell carcinomas exhibit variable sensitivity to inhibitors of the PI3K(phosphoinositide 3-kinase)/mTOR(mammalian target of rapamycin) pathway, an important target of genomic alterations in this cancer type. The MEK(mitogen-activated protein kinase kinase)/ERK(extracel...

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Publicado no:Clin Cancer Res
Main Authors: Mohan, Suresh, Broek, Robert Vander, Shah, Sujay, Eytan, Danielle F., Pierce, Matthew L., Carlson, Sophie G., Coupar, Jamie F., Zhang, Jialing, Cheng, Hui, Chen, Zhong, Van Waes, Carter
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558307/
https://ncbi.nlm.nih.gov/pubmed/25977343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-3377
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