MEK Inhibitor PD-0325901 Overcomes Resistance to CK2 Inhibitor CX-4945 and Exhibits Anti-Tumor Activity in Head and Neck Cancer

The serine-threonine kinase CK2 exhibits genomic alterations and aberrant overexpression in human head and neck squamous cell carcinomas (HNSCC). Here, we investigated the effects of CK2 inhibitor CX-4945 in human HNSCC cell lines and xenograft models. The IC(50's )of CX-4945 for 9 UM-SCC cell...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Int J Biol Sci
Prif Awduron: Bian, Yansong, Han, Jiawei, Kannabiran, Vishnu, Mohan, Suresh, Cheng, Hui, Friedman, Jay, Zhang, Luo, VanWaes, Carter, Chen, Zhong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Ivyspring International Publisher 2015
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366640/
https://ncbi.nlm.nih.gov/pubmed/25798061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.10745
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