Real-time relationship between PKA biochemical signal network dynamics and increased action potential firing rate in heart pacemaker cells

cAMP-PKA protein kinase is a key nodal signaling pathway that regulates a wide range of heart pacemaker cell functions. These functions are predicted to be involved in regulation of spontaneous action potential (AP) generation of these cells. Here we investigate if the kinetics and stoichiometry of...

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Udgivet i:J Mol Cell Cardiol
Main Authors: Yaniv, Yael, Ganesan, Ambhighainath, Yang, Dongmei, Ziman, Bruce D., Lyashkov, Alexey E., Levchenko, Andre, Zhang, Jin, Lakatta, Edward G.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558217/
https://ncbi.nlm.nih.gov/pubmed/26241846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2015.07.024
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