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Ligand-independent EGFR signaling

Constitutive activation of the EGFR is common in cancer due to EGFR wild type (EGFRwt) overexpression or the presence of mutant EGFR. Signaling by constitutively active NSCLC EGFR mutants or the EGFRvIII mutant in glioblastoma has been studied intensively and the downstream signals are known. Normal...

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Detalles Bibliográficos
Publicado en:Cancer Res
Main Authors: Guo, Gao, Gong, Ke, Wohlfeld, Bryan, Hatanpaa, Kimmo J., Zhao, Dawen, Habib, Amyn A.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558210/
https://ncbi.nlm.nih.gov/pubmed/26282175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0989
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