Primary resistance to EGFR inhibition in glioblastoma is mediated by a TNF-JNK-Axl-ERK signaling axis

Aberrant EGFR signaling is widespread in cancer, making the EGFR an important target for therapy. EGFR gene amplification and mutation are common in glioblastoma (GBM), but EGFR inhibition has not been effective in treating this tumor. Here, we propose that primary resistance to EGFR inhibition in g...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Guo, Gao, Gong, Ke, Ali, Sonia, Ali, Neha, Shallwani, Shahzad, Hatanpaa, Kimmo J., Pan, Edward, Mickey, Bruce, Burma, Sandeep, Wang, David H., Kesari, Santosh, Sarkaria, Jann N, Zhao, Dawen, Habib, Amyn A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5529219/
https://ncbi.nlm.nih.gov/pubmed/28604685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4584
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