Constitutive and ligand-induced EGFR signaling triggers distinct and mutually exclusive downstream signaling networks

EGFR overexpression plays an important oncogenic role in cancer. Regular EGFR protein levels are increased in cancer cells and the receptor then becomes constitutively active. However, downstream signals generated by constitutively activated EGFR are unknown. Here we report that the overexpressed EG...

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Publicado no:Nat Commun
Main Authors: Chakraborty, Sharmistha, Li, Li, Puliyappadamba, VineshkumarThidil, Guo, Gao, Hatanpaa, Kimmo J., Mickey, Bruce, Souza, Rhonda F., Vo, Peggy, Herz, Joachim, Chen, Mei-Ru, Boothman, David A., Pandita, Tej K., Wang, David H., Sen, Ganes C., Habib, Amyn A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268886/
https://ncbi.nlm.nih.gov/pubmed/25503978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6811
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