Presenilin 1 maintains lysosomal Ca(2+) homeostasis by regulating vATPase-mediated lysosome acidification

Presenilin-1 (PS1) deletion or Alzheimer’s Disease (AD)-linked mutations disrupt lysosomal acidification and proteolysis, which inhibits autophagy. Here, we establish that this phenotype stems from impaired glycosylation and instability of vATPase V0a1 subunit causing deficient lysosomal vATPase ass...

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Udgivet i:Cell Rep
Main Authors: Lee, Ju-Hyun, McBrayer, Mary Kate, Wolfe, Devin M., Haslett, Luke J., Kumar, Asok, Sato, Yutaka, Lie, Pearl P. Y., Mohan, Panaiyur, Coffey, Erin E., Kompella, Uday, Mitchell, Claire H., Lloyd-Evans, Emyr, Nixon, Ralph A.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558203/
https://ncbi.nlm.nih.gov/pubmed/26299959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.07.050
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