Inhibition of αIIbβ3 Ligand Binding by an αIIb Peptide that Clasps the Hybrid Domain to the βI Domain of β3

Agonist-stimulated platelet activation triggers conformational changes of integrin αIIbβ3, allowing fibrinogen binding and platelet aggregation. We have previously shown that an octapeptide, (p1)YMESRADR(8), corresponding to amino acids 313–320 of the β-ribbon extending from the β-propeller domain o...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lee, Wen Hwa, Schaffner-Reckinger, Elisabeth, Tsoukatos, Demokritos C., Aylward, Kelly, Moussis, Vassilios, Tsikaris, Vassilios, Trypou, Paraskevi, Egot, Marion, Baruch, Dominique, Kieffer, Nelly, Bachelot-Loza, Christilla
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557944/
https://ncbi.nlm.nih.gov/pubmed/26332040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134952
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