Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models

BACKGROUND & AIMS: Sustained activation of the cytosolic calcium concentration induces injury to pancreatic acinar cells and necrosis. The calcium release–activated calcium modulator ORAI1 is the most abundant Ca(2+) entry channel in pancreatic acinar cells; it sustains calcium overload in mice...

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Detalhes bibliográficos
Publicado no:Gastroenterology
Main Authors: Wen, Li, Voronina, Svetlana, Javed, Muhammad A., Awais, Muhammad, Szatmary, Peter, Latawiec, Diane, Chvanov, Michael, Collier, David, Huang, Wei, Barrett, John, Begg, Malcolm, Stauderman, Ken, Roos, Jack, Grigoryev, Sergey, Ramos, Stephanie, Rogers, Evan, Whitten, Jeff, Velicelebi, Gonul, Dunn, Michael, Tepikin, Alexei V., Criddle, David N., Sutton, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: W.B. Saunders 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556985/
https://ncbi.nlm.nih.gov/pubmed/25917787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2015.04.015
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