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Engineering an analog-sensitive CDK12 cell line using CRISPR/Cas
The RNA Polymerase II C-terminal domain (CTD) kinase CDK12 has been implicated as a tumor suppressor and regulator of DNA damage response genes. Although much has been learned about CDK12 and its activity, due to the lack of a specific inhibitor and the complications posed by long term RNAi depletio...
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| Vydáno v: | Biochim Biophys Acta |
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| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4556607/ https://ncbi.nlm.nih.gov/pubmed/26189575 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagrm.2015.07.010 |
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