Renal fibrosis is not reduced by blocking transforming growth factor-β signaling in matrix-producing interstitial cells

Transforming growth factor-β (TGF-β) strongly promotes renal tubulointerstitial fibrosis, but the cellular target that mediates its profibrotic actions has not been clearly identified. While in vitro data suggest that TGF-β-induced matrix production is mediated by renal fibroblasts, the role of thes...

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Veröffentlicht in:Kidney Int
Hauptverfasser: Neelisetty, Surekha, Alford, Catherine, Reynolds, Karen, Woodbury, Luke, Nlandu-khodo, Stellor, Yang, Haichun, Fogo, Agnes B., Hao, Chuan-Ming, Harris, Raymond C., Zent, Roy, Gewin, Leslie
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556568/
https://ncbi.nlm.nih.gov/pubmed/25760325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2015.51
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