Inactivation of Tsc2 in Abcg2 lineage-derived cells drives the appearance of polycystic lesions and fibrosis in the adult kidney

Tuberous sclerosis complex 2 (TSC2), or tuberin, is a pivotal regulator of the mechanistic target of rapamycin signaling pathway that controls cell survival, proliferation, growth, and migration. Loss of Tsc2 function manifests in organ-specific consequences, the mechanisms of which remain incomplet...

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發表在:Am J Physiol Renal Physiol
Main Authors: Gewin, Leslie S., Summers, Megan E., Harral, Julie W., Gaskill, Christa F., Khodo, Stellor Nlandu, Neelisetty, Surekha, Sullivan, Timothy M., Hopp, Katharina, Reese, J. Jeffrey, Klemm, Dwight J., Kon, Valentina, Ess, Kevin C., Shi, Wei, Majka, Susan M.
格式: Artigo
語言:Inglês
出版: American Physiological Society 2019
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879939/
https://ncbi.nlm.nih.gov/pubmed/31461347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00629.2018
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