Inactivation of Tsc2 in Abcg2 lineage-derived cells drives the appearance of polycystic lesions and fibrosis in the adult kidney

Tuberous sclerosis complex 2 (TSC2), or tuberin, is a pivotal regulator of the mechanistic target of rapamycin signaling pathway that controls cell survival, proliferation, growth, and migration. Loss of Tsc2 function manifests in organ-specific consequences, the mechanisms of which remain incomplet...

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Detalhes bibliográficos
Publicado no:Am J Physiol Renal Physiol
Main Authors: Gewin, Leslie S., Summers, Megan E., Harral, Julie W., Gaskill, Christa F., Khodo, Stellor Nlandu, Neelisetty, Surekha, Sullivan, Timothy M., Hopp, Katharina, Reese, J. Jeffrey, Klemm, Dwight J., Kon, Valentina, Ess, Kevin C., Shi, Wei, Majka, Susan M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879939/
https://ncbi.nlm.nih.gov/pubmed/31461347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00629.2018
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