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Deleting the TGF-β Receptor Attenuates Acute Proximal Tubule Injury

TGF-β is a profibrotic growth factor in CKD, but its role in modulating the kidney’s response to AKI is not well understood. The proximal tubule epithelial cell, which is the main cellular target of AKI, expresses high levels of both TGF-β and its receptors. To determine how TGF-β signaling in this...

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Main Authors: Gewin, Leslie, Vadivelu, Sangeetha, Neelisetty, Surekha, Srichai, Manakan B., Paueksakon, Paisit, Pozzi, Ambra, Harris, Raymond C., Zent, Roy
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Nephrology 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507360/
https://ncbi.nlm.nih.gov/pubmed/23160515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012020139
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