Deleting the TGF-β Receptor Attenuates Acute Proximal Tubule Injury

TGF-β is a profibrotic growth factor in CKD, but its role in modulating the kidney’s response to AKI is not well understood. The proximal tubule epithelial cell, which is the main cellular target of AKI, expresses high levels of both TGF-β and its receptors. To determine how TGF-β signaling in this...

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Bibliografiske detaljer
Main Authors: Gewin, Leslie, Vadivelu, Sangeetha, Neelisetty, Surekha, Srichai, Manakan B., Paueksakon, Paisit, Pozzi, Ambra, Harris, Raymond C., Zent, Roy
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2012
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507360/
https://ncbi.nlm.nih.gov/pubmed/23160515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012020139
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