MD-2 as the target of a novel small molecule, L6H21, in the attenuation of LPS-induced inflammatory response and sepsis

BACKGROUND AND PURPOSE: Myeloid differentiation 2 (MD-2) recognizes LPS, which is required for TLR4 activation, and represents an attractive therapeutic target for severe inflammatory disorders. We previously found that a chalcone derivative, L6H21, could inhibit LPS-induced overexpression of TNF-α...

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Опубликовано в: :Br J Pharmacol
Главные авторы: Wang, Yi, Shan, Xiaoou, Chen, Gaozhi, Jiang, Lili, Wang, Zhe, Fang, Qilu, Liu, Xing, Wang, Jingying, Zhang, Yali, Wu, Wencan, Liang, Guang
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley & Sons, Ltd 2015
Предметы:
Research Papers
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556476/
https://ncbi.nlm.nih.gov/pubmed/26076332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13221
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