Discovery of new MD2 inhibitor from chalcone derivatives with anti-inflammatory effects in LPS-induced acute lung injury

Acute lung injury (ALI) is a life-threatening acute inflammatory disease with limited options available for therapy. Myeloid differentiation protein 2, a co-receptor of TLR4, is absolutely required for TLR4 sense LPS, and represents an attractive target for treating severe inflammatory diseases. In...

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Publicado no:Sci Rep
Main Authors: Zhang, Yali, Wu, Jianzhang, Ying, Shilong, Chen, Gaozhi, Wu, Beibei, Xu, Tingting, Liu, Zhiguo, Liu, Xing, Huang, Lehao, Shan, Xiaoou, Dai, Yuanrong, Liang, Guang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846832/
https://ncbi.nlm.nih.gov/pubmed/27118147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25130
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