Synthesis and biological evaluation of novel indole-2-one and 7-aza-2-oxindole derivatives as anti-inflammatory agents

Sepsis, a typically acute inflammatory disease, is the biggest cause of death in ICU (intensive care unit). Novel anti-inflammatory alternatives are still in urgent need. In this study, we designed and synthesized 30 indole-2-one and 7-aza-2-oxindole derivatives based on the skeleton of tenidap, and...

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Bibliografske podrobnosti
Main Authors: Chen, Gaozhi, Jiang, Lili, Dong, Lili, Wang, Zhe, Xu, Fengli, Ding, Ting, Fu, Lili, Fang, Qilu, Liu, Zhiguo, Shan, Xiaoou, Liang, Guang
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2014
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207570/
https://ncbi.nlm.nih.gov/pubmed/25378906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S65997
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