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Classic reaction kinetics can explain complex patterns of antibiotic action

Finding optimal dosing strategies for treating bacterial infections is extremely difficult, and improving therapy requires costly and time-intensive experiments. To date, an incomplete mechanistic understanding of drug effects has limited our ability to make accurate quantitative predictions of drug...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: zur Wiesch, P. Abel, Abel, S., Gkotzis, S., Ocampo, P., Engelstädter, J., Hinkley, T., Magnus, C., Waldor, M. K., Udekwu, K., Cohen, T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4554720/
https://ncbi.nlm.nih.gov/pubmed/25972005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaa8760
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