Single methylation of 23S rRNA triggers late steps of 50S ribosomal subunit assembly

Ribosome biogenesis requires multiple assembly factors. In Escherichia coli, deletion of RlmE, the methyltransferase responsible for the 2′-O-methyluridine modification at position 2552 (Um2552) in helix 92 of the 23S rRNA, results in slow growth and accumulation of the 45S particle. We demonstrate...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Arai, Taiga, Ishiguro, Kensuke, Kimura, Satoshi, Sakaguchi, Yuriko, Suzuki, Takeo, Suzuki, Tsutomu
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4553768/
https://ncbi.nlm.nih.gov/pubmed/26261349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1506749112
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