Single methylation of 23S rRNA triggers late steps of 50S ribosomal subunit assembly

Ribosome biogenesis requires multiple assembly factors. In Escherichia coli, deletion of RlmE, the methyltransferase responsible for the 2′-O-methyluridine modification at position 2552 (Um2552) in helix 92 of the 23S rRNA, results in slow growth and accumulation of the 45S particle. We demonstrate...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Arai, Taiga, Ishiguro, Kensuke, Kimura, Satoshi, Sakaguchi, Yuriko, Suzuki, Takeo, Suzuki, Tsutomu
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4553768/
https://ncbi.nlm.nih.gov/pubmed/26261349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1506749112
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