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Depletion of S-adenosylmethionine impacts on ribosome biogenesis through hypomodification of a single rRNA methylation

S-adenosylmethionine (SAM) is an essential metabolite and a methyl group donor in all living organisms. The intracellular SAM concentration is tightly regulated, and depletion causes hypomethylation of substrates, growth defects and pathological consequences. In the emerging field of epitranscriptom...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Ishiguro, Kensuke, Arai, Taiga, Suzuki, Tsutomu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486555/
https://ncbi.nlm.nih.gov/pubmed/30799486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz111
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