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Depletion of S-adenosylmethionine impacts on ribosome biogenesis through hypomodification of a single rRNA methylation
S-adenosylmethionine (SAM) is an essential metabolite and a methyl group donor in all living organisms. The intracellular SAM concentration is tightly regulated, and depletion causes hypomethylation of substrates, growth defects and pathological consequences. In the emerging field of epitranscriptom...
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| Gepubliceerd in: | Nucleic Acids Res |
|---|---|
| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Oxford University Press
2019
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6486555/ https://ncbi.nlm.nih.gov/pubmed/30799486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz111 |
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