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Depletion of S-adenosylmethionine impacts on ribosome biogenesis through hypomodification of a single rRNA methylation

S-adenosylmethionine (SAM) is an essential metabolite and a methyl group donor in all living organisms. The intracellular SAM concentration is tightly regulated, and depletion causes hypomethylation of substrates, growth defects and pathological consequences. In the emerging field of epitranscriptom...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Ishiguro, Kensuke, Arai, Taiga, Suzuki, Tsutomu
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486555/
https://ncbi.nlm.nih.gov/pubmed/30799486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz111
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