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Activation of MET pathway predicts poor outcome to cetuximab in patients with recurrent or metastatic head and neck cancer
BACKGROUND: Activation of the MET oncogene promotes tumor growth, invasion and metastasis in several tumor types. Additionally, MET is activated as a compensatory pathway in the presence of EGFR blockade, thus resulting in a mechanism of resistance to EGFR inhibitors. METHODS: We have investigated t...
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| Gepubliceerd in: | J Transl Med |
|---|---|
| Hoofdauteurs: | , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
BioMed Central
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4552997/ https://ncbi.nlm.nih.gov/pubmed/26319934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0633-7 |
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