Activation of MET pathway predicts poor outcome to cetuximab in patients with recurrent or metastatic head and neck cancer

BACKGROUND: Activation of the MET oncogene promotes tumor growth, invasion and metastasis in several tumor types. Additionally, MET is activated as a compensatory pathway in the presence of EGFR blockade, thus resulting in a mechanism of resistance to EGFR inhibitors. METHODS: We have investigated t...

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Udgivet i:J Transl Med
Main Authors: Madoz-Gúrpide, Juan, Zazo, Sandra, Chamizo, Cristina, Casado, Victoria, Caramés, Cristina, Gavín, Eduardo, Cristóbal, Ion, García-Foncillas, Jesús, Rojo, Federico
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552997/
https://ncbi.nlm.nih.gov/pubmed/26319934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0633-7
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