Development of APE1 enzymatic DNA repair assays: low APE1 activity is associated with increase lung cancer risk

The key role of DNA repair in removing DNA damage and minimizing mutations makes it an attractive target for cancer risk assessment and prevention. Here we describe the development of a robust assay for apurinic/apyrimidinic (AP) endonuclease 1 (APE1; APEX1), an essential enzyme involved in the repa...

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Vydáno v:Carcinogenesis
Hlavní autoři: Sevilya, Ziv, Leitner-Dagan, Yael, Pinchev, Mila, Kremer, Ran, Elinger, Dalia, Lejbkowicz, Flavio, Rennert, Hedy S., Freedman, Laurence S., Rennert, Gad, Paz-Elizur, Tamar, Livneh, Zvi
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
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Original Manuscript
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552243/
https://ncbi.nlm.nih.gov/pubmed/26045303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgv082
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