Development of APE1 enzymatic DNA repair assays: low APE1 activity is associated with increase lung cancer risk

The key role of DNA repair in removing DNA damage and minimizing mutations makes it an attractive target for cancer risk assessment and prevention. Here we describe the development of a robust assay for apurinic/apyrimidinic (AP) endonuclease 1 (APE1; APEX1), an essential enzyme involved in the repa...

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Detalhes bibliográficos
Publicado no:Carcinogenesis
Main Authors: Sevilya, Ziv, Leitner-Dagan, Yael, Pinchev, Mila, Kremer, Ran, Elinger, Dalia, Lejbkowicz, Flavio, Rennert, Hedy S., Freedman, Laurence S., Rennert, Gad, Paz-Elizur, Tamar, Livneh, Zvi
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Original Manuscript
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552243/
https://ncbi.nlm.nih.gov/pubmed/26045303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgv082
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