Enzymatic MPG DNA repair assays for two different oxidative DNA lesions reveal associations with increased lung cancer risk

DNA repair is a major mechanism for minimizing mutations and reducing cancer risk. Here, we present the development of reproducible and specific enzymatic assays for methylpurine DNA glycosylase (MPG) repairing the oxidative lesions 1,N6-ethenoadenine (εA) and hypoxanthine (Hx) in peripheral blood m...

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Veröffentlicht in:Carcinogenesis
Hauptverfasser: Leitner-Dagan, Yael, Sevilya, Ziv, Pinchev, Mila, Kremer, Ran, Elinger, Dalia, Rennert, Hedy S., Schechtman, Edna, Freedman, Laurence, Rennert, Gad, Livneh, Zvi, Paz-Elizur, Tamar
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303808/
https://ncbi.nlm.nih.gov/pubmed/25355292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgu214
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