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DNA sequence context greatly affects the accuracy of bypass across an ultraviolet light 6-4 photoproduct in mammalian cells

Translesion DNA synthesis (TLS) is a DNA damage tolerance mechanism carried out by low-fidelity DNA polymerases that bypass DNA lesions, which overcomes replication stalling. Despite the miscoding nature of most common DNA lesions, several of them are bypassed in mammalian cells in a relatively accu...

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Detalhes bibliográficos
Publicado no:Mutat Res
Main Authors: Shriber, Pola, Leitner-Dagan, Yael, Yael, Nicholas, Paz-Elizur, Tamar, Livneh, Zvi
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871125/
https://ncbi.nlm.nih.gov/pubmed/26302378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2015.08.002
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