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Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A
Autophagy is a cellular catabolic process critical for cell viability and homoeostasis. Inhibition of mammalian target of rapamycin (mTOR) complex-1 (mTORC1) activates autophagy. A puzzling observation is that amino acid starvation triggers more rapid autophagy than pharmacological inhibition of mTO...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4552084/ https://ncbi.nlm.nih.gov/pubmed/26310906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9048 |
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