Dissecting the role of distinct OCT4-SOX2 heterodimer configurations in pluripotency

The transcription factors OCT4 and SOX2 are required for generating induced pluripotent stem cells (iPSCs) and for maintaining embryonic stem cells (ESCs). OCT4 and SOX2 associate and bind to DNA in different configurations depending on the arrangement of their individual DNA binding elements. Here...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Tapia, Natalia, MacCarthy, Caitlin, Esch, Daniel, Gabriele Marthaler, Adele, Tiemann, Ulf, Araúzo-Bravo, Marcos J., Jauch, Ralf, Cojocaru, Vlad, Schöler, Hans R.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551974/
https://ncbi.nlm.nih.gov/pubmed/26314899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13533
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