Integrative genomic analysis in K562 chronic myelogenous leukemia cells reveals that proximal NCOR1 binding positively regulates genes that govern erythroid differentiation and Imatinib sensitivity

To define the functions of NCOR1 we developed an integrative analysis that combined ENCODE and NCI-60 data, followed by in vitro validation. NCOR1 and H3K9me3 ChIP-Seq, FAIRE-seq and DNA CpG methylation interactions were related to gene expression using bootstrapping approaches. Most NCOR1 combinati...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Long, Mark D., van den Berg, Patrick R., Russell, James L., Singh, Prashant K., Battaglia, Sebastiano, Campbell, Moray J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Gene regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551916/
https://ncbi.nlm.nih.gov/pubmed/26117541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv642
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