Integrative genomic analysis in K562 chronic myelogenous leukemia cells reveals that proximal NCOR1 binding positively regulates genes that govern erythroid differentiation and Imatinib sensitivity

To define the functions of NCOR1 we developed an integrative analysis that combined ENCODE and NCI-60 data, followed by in vitro validation. NCOR1 and H3K9me3 ChIP-Seq, FAIRE-seq and DNA CpG methylation interactions were related to gene expression using bootstrapping approaches. Most NCOR1 combinati...

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發表在:Nucleic Acids Res
Main Authors: Long, Mark D., van den Berg, Patrick R., Russell, James L., Singh, Prashant K., Battaglia, Sebastiano, Campbell, Moray J.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2015
主題:
Gene regulation, Chromatin and Epigenetics
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551916/
https://ncbi.nlm.nih.gov/pubmed/26117541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv642
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