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PPARβ/δ recruits NCOR and regulates transcription reinitiation of ANGPTL4
In the absence of ligands, the nuclear receptor PPARβ/δ recruits the NCOR and SMRT corepressors, which form complexes with HDAC3, to canonical target genes. Agonistic ligands cause dissociation of corepressors and enable enhanced transcription. Vice versa, synthetic inverse agonists augment corepres...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6765110/ https://ncbi.nlm.nih.gov/pubmed/31428774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz685 |
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