PPARβ/δ recruits NCOR and regulates transcription reinitiation of ANGPTL4

In the absence of ligands, the nuclear receptor PPARβ/δ recruits the NCOR and SMRT corepressors, which form complexes with HDAC3, to canonical target genes. Agonistic ligands cause dissociation of corepressors and enable enhanced transcription. Vice versa, synthetic inverse agonists augment corepres...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nucleic Acids Res
Egile Nagusiak: Legrand, Nathalie, Bretscher, Clemens L, Zielke, Svenja, Wilke, Bernhard, Daude, Michael, Fritz, Barbara, Diederich, Wibke E, Adhikary, Till
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2019
Gaiak:
Gene regulation, Chromatin and Epigenetics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765110/
https://ncbi.nlm.nih.gov/pubmed/31428774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz685
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