Identification of human telomerase assembly inhibitors enabled by a novel method to produce hTERT

Telomerase is the enzyme that maintains the length of telomeres. It is minimally constituted of two components: a core reverse transcriptase protein (hTERT) and an RNA (hTR). Despite its significance as an almost universal cancer target, the understanding of the structure of telomerase and the optim...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nucleic Acids Res
Hlavní autoři: Kellermann, Guillaume, Kaiser, Markus, Dingli, Florent, Lahuna, Olivier, Naud-Martin, Delphine, Mahuteau-Betzer, Florence, Loew, Damarys, Ségal-Bendirdjian, Evelyne, Teulade-Fichou, Marie-Paule, Bombard, Sophie
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Methods Online
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551907/
https://ncbi.nlm.nih.gov/pubmed/25958399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv425
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky