Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

Proteasomes are central regulators of protein homeostasis in eukaryotes. Proteasome function is vulnerable to environmental insults, cellular protein imbalance and targeted pharmaceuticals. Yet, mechanisms that cells deploy to counteract inhibition of this central regulator are little understood. To...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Tsvetkov, Peter, Mendillo, Marc L, Zhao, Jinghui, Carette, Jan E, Merrill, Parker H, Cikes, Domagoj, Varadarajan, Malini, van Diemen, Ferdy R, Penninger, Josef M, Goldberg, Alfred L, Brummelkamp, Thijn R, Santagata, Sandro, Lindquist, Susan
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551903/
https://ncbi.nlm.nih.gov/pubmed/26327695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08467
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