Quantitative Signaling and Structure-Activity Analyses Demonstrate Functional Selectivity at the Nociceptin/Orphanin FQ Opioid Receptor

Comprehensive studies that consolidate selective ligands, quantitative comparisons of G protein versus arrestin-2/3 coupling, together with structure-activity relationship models for G protein–coupled receptor (GPCR) systems are less commonly employed. Here we examine biased signaling at the nocicep...

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Publicat a:Mol Pharmacol
Autors principals: Chang, Steven D., Mascarella, S. Wayne, Spangler, Skylar M., Gurevich, Vsevolod V., Navarro, Hernan A., Carroll, F. Ivy, Bruchas, Michael R.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2015
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551045/
https://ncbi.nlm.nih.gov/pubmed/26134494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.099150
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