Analysis of YFP(J16)-R6/2 reporter mice and postmortem brains reveals early pathology and increased vulnerability of callosal axons in Huntington's disease

Cumulative evidence indicates that the onset and severity of Huntington's disease (HD) symptoms correlate with connectivity deficits involving specific neuronal populations within cortical and basal ganglia circuits. Brain imaging studies and pathological reports further associated these defici...

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Publicat a:Hum Mol Genet
Autors principals: Gatto, Rodolfo G., Chu, Yaping, Ye, Allen Q., Price, Steven D., Tavassoli, Ehsan, Buenaventura, Andrea, Brady, Scott T., Magin, Richard L., Kordower, Jeffrey H., Morfini, Gerardo A.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550824/
https://ncbi.nlm.nih.gov/pubmed/26123489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv248
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